*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ2850000
CHEMICAL NAME           : (2)Benzopyrano(3,4-g)indole,
                          1,2,3,5a,7,11b,11c-octahydro-9,10-dimethoxy-7-ethoxy-
                          1-methyl-, hydrochloride
CAS REGISTRY NUMBER     : 75917-42-9
LAST UPDATED            : 199512
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H27-N-O4.Cl-H
MOLECULAR WEIGHT        : 381.94
WISWESSER LINE NOTATION : T C5 B666 DN KO GU NU PUTJ D1 LO2 OO1 PO1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   9,10-Dimethoxy-7-ethoxy-1-methyl-1,2,3,5a,7,11b,11c-octahydro(2)benzopyr
     ano(3,4-g)indole HCl
   * 9-O-Ethyl lycorenine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 765 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   1,30,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 106 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   1,30,1980
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >60 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Gastrointestinal - changes in structure or function of salivary glands
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   CYLPDN Zhongguo Yaoli Xuebao.  Acta Pharmacologica Sinica.  Chinese Journal
   of Pharmacology.  (China International Book Trading Corp., POB 2820,
   Beijing, Peop. Rep. China)  V.1-    1980-  Volume(issue)/page/year:
   1,30,1980
 
                            *** END OF RECORD ***