*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DJ2623100
CHEMICAL NAME           : (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6a-al
                          phah)-one, 1,2,12,12a-alpha-tetrahydro-
                          2-alpha-isopropyl-8,9-dimethoxy-
CAS REGISTRY NUMBER     : 6659-45-6
OTHER CAS REGISTRY NOS. : 12379-65-6
LAST UPDATED            : 199512
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C23-H24-O6
MOLECULAR WEIGHT        : 396.47
COMPOUND DESCRIPTOR     : Agricultural Chemical
SYNONYMS/TRADE NAMES :
   * Dihydrorotenone
   * Rotenone, dihydro-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 42,364,1953
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IECHAD Industrial and Engineering Chemistry.  (Washington, DC)  V.15-62,
   1923-70.  For publisher information, see CHMTBL.  Volume(issue)/page/year:
   29,429,1937
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   IECHAD Industrial and Engineering Chemistry.  (Washington, DC)  V.15-62,
   1923-70.  For publisher information, see CHMTBL.  Volume(issue)/page/year:
   29,429,1937
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4616 mg/kg/57W-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 42,364,1953
 
                            *** END OF RECORD ***