*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DG9700000
CHEMICAL NAME           : Benzoic acid, 1,3-dithiolan-2-ylidenehydrazide
CAS REGISTRY NUMBER     : 62303-19-9
OTHER CAS REGISTRY NOS. : 77272-72-1
LAST UPDATED            : 199412
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C10-H10-N2-O-S2
MOLECULAR WEIGHT        : 238.34
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 2-Benzoylhydrazono-1,3-dithiolane
   * YU 7802
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 72800 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   CIYPDA Sichuan Yixueyuan Xuebao.  Acta Akademiae Medicinae Sichuan.
   (Beijing, Peop. Rep. China) V.1-16, 1970-85.  For publisher information, see
   HYDXET.  Volume(issue)/page/year: 15,318,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 111 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   CIYPDA Sichuan Yixueyuan Xuebao.  Acta Akademiae Medicinae Sichuan.
   (Beijing, Peop. Rep. China) V.1-16, 1970-85.  For publisher information, see
   HYDXET.  Volume(issue)/page/year: 15,318,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 383 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   CIYPDA Sichuan Yixueyuan Xuebao.  Acta Akademiae Medicinae Sichuan.
   (Beijing, Peop. Rep. China) V.1-16, 1970-85.  For publisher information, see
   HYDXET.  Volume(issue)/page/year: 15,318,1984
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1652 mg/kg/13W-C
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes in urine composition
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   CIYPDA Sichuan Yixueyuan Xuebao.  Acta Akademiae Medicinae Sichuan.
   (Beijing, Peop. Rep. China) V.1-16, 1970-85.  For publisher information, see
   HYDXET.  Volume(issue)/page/year: 15,318,1984
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 200 ug/L
REFERENCE :
   CIYPDA Sichuan Yixueyuan Xuebao.  Acta Akademiae Medicinae Sichuan.
   (Beijing, Peop. Rep. China) V.1-16, 1970-85.  For publisher information, see
   HYDXET.  Volume(issue)/page/year: 15,318,1984
 
                            *** END OF RECORD ***