*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DG3345000
CHEMICAL NAME : Benzoic acid,
(1-(4-((3-amino-2,3,6-trideoxy-alpha,L-lyxo-hexopyran
osyl)oxy)-1,2,3,4,6,1 1-
hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-na
phthacenyl)ethylidene )hydrazide, (2S-cis)-
CAS REGISTRY NUMBER : 54083-22-6
BEILSTEIN REFERENCE NO. : 1417621
LAST UPDATED : 199703
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C34-H35-N3-O10
MOLECULAR WEIGHT : 645.72
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Benzoylhydrazone daunorubicin
* Daunomycin benzoylhydrazone
* Rubidazon
* Rubidazone
* Zorubicin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
38,167,1989
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 22500 ug/kg/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York,
Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978-
Volume(issue)/page/year: 2,31,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 75 mg/kg/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York,
Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978-
Volume(issue)/page/year: 2,31,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 42500 ug/kg/5D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York,
Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978-
Volume(issue)/page/year: 2,31,1979
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press,
c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)-
25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year:
19,641,1983
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 500 ug/L
REFERENCE :
CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York,
Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978-
Volume(issue)/page/year: 2,31,1979
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Cells - not otherwise specified
DOSE/DURATION : 500 ug/L
REFERENCE :
CCPHDZ Cancer Chemotherapy and Pharmacology. (Springer-Verlag New York,
Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1978-
Volume(issue)/page/year: 2,31,1979
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 2150 ug/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
38,167,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2089
No. of Facilities: 8 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 229 (estimated)
No. of Female Employees: 82 (estimated)
*** END OF RECORD ***