*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DG3065000
CHEMICAL NAME           : Benzoic acid, 3-amino-4-propoxy-,
                          2-(diethylamino)ethyl ester, hydrochloride
CAS REGISTRY NUMBER     : 5875-06-9
LAST UPDATED            : 199504
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C16-H26-N2-O3.Cl-H
MOLECULAR WEIGHT        : 330.90
WISWESSER LINE NOTATION : 3OR BZ DVO2N2&2 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Alcaine
   * 3-Amino-4-propoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride
   * beta-(Diethylamino)ethyl 3-amino-4-n-propoxybenzoate hydrochloride
   * 2-Diethylaminoethyl 3-amino-4-propoxybenzoate hydrochloride
   * Keracaine
   * Ophthain
   * Ophthaine hydrochloride
   * Proparacaine hydrochloride
   * Proxymetacaine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 64 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 40,133,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3371 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 123,269,1958

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X3223
       No. of Facilities: 412 (estimated)
       No. of Industries: 2
       No. of Occupations: 7
       No. of Employees: 3442 (estimated)
       No. of Female Employees: 2127 (estimated)

 
                            *** END OF RECORD ***