*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DF6473550
CHEMICAL NAME           : 7-Benzofurancarboxamide,
                          2,3-dihydro-5-chloro-2,2-dimethyl-N-(8-methyl-8-azabi
                          cyclo(3.2.1)oct-3-yl) -, endo-, (Z)-2-butenedioate
                          (1:1)
CAS REGISTRY NUMBER     : 123482-23-5
LAST UPDATED            : 199510
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H25-Cl-N2-O2.C4-H4-O4
MOLECULAR WEIGHT        : 464.99
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * LY 277359 maleate
   * Zatosetron maleate
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 38220 mg/kg/1Y-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   22,494,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 3650 mg/kg/1Y-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 18,61,1995
 
                            *** END OF RECORD ***