*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DF4736000
CHEMICAL NAME           : 1,4-Benzodioxin-2-methanol,
                          alpha,alpha'-(iminobis(methylene))bis(2,3-dihydro-,
                          (2R-(2R*(alpha-S*(alpha'R*(2'S*)))))-,
                          methanesulfonate (salt)
CAS REGISTRY NUMBER     : 81737-62-4
LAST UPDATED            : 199606
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C20-H23-N-O6.C-H4-O3-S
MOLECULAR WEIGHT        : 469.55
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * CGS 10078B
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4490 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,121,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >6287 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,121,1985
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >943 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,121,1985
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >1257 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,121,1985
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20937 mg/kg/13W-I
TOXIC EFFECTS :
   Endocrine - hypoglycemia
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,121,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 11669 mg/kg/13W-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Gastrointestinal - nausea or vomiting
REFERENCE :
   NCDREP New Cardiovascular Drugs.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036)  1985-  Volume(issue)/page/year: 3,121,1985
 
                            *** END OF RECORD ***