*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DF2378200
CHEMICAL NAME           : 2H-1,5-Benzodiazepin-2-one,
                          1,3-dihydro-4-(dimethylamino)-3-((dimethylamino)methy
                          lene)-
CAS REGISTRY NUMBER     : 87295-93-0
LAST UPDATED            : 199306
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C14-H18-N4-O
MOLECULAR WEIGHT        : 258.36
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   4-(Dimethylamino)-3-((dimethylamino)methylene)-1,3-dihydro-2H-1,5-benzod
     iazepin-2-one
   *   4-(Dimetilammino)-3-((dimetilammino)metilen)-1,3-diidro-2H-1,5-benzodiaz
     epin-2-oni
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 38,546,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 38,546,1983
 
                            *** END OF RECORD ***