*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DF2367730
CHEMICAL NAME           : 2H-1,4-Benzodiazepin-2-one,
                          1,3-dihydro-7-chloro-5-(2-chlorophenyl)-1-(2-((4-
                          methylphenyl)sulfonyl)ethyl)-
CAS REGISTRY NUMBER     : 86273-92-9
LAST UPDATED            : 198909
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C24-H20-Cl2-N2-O3-S
MOLECULAR WEIGHT        : 487.42
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Inn Tolufazepam
   *   1-(4'-Methylphenylsulfonyl)ethyl-5-(2-chlorophenyl)-7-chloro-2H-1,4-benz
     odiazepin-2-one
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1350 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - changes in motor activity (specific assay)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 293,57,1988
 
                            *** END OF RECORD ***