*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DE9750000
CHEMICAL NAME           : 2H-1,4-Benzodiazepin-2-one,
                          7-amino-1,3-dihydro-5-phenyl-
CAS REGISTRY NUMBER     : 4928-02-3
BEILSTEIN REFERENCE NO. : 0535813
REFERENCE               : 5-25-15-00274 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C15-H13-N3-O
MOLECULAR WEIGHT        : 251.31
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 7-Amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
   * 7-Aminonitrazepam
   * Ro 5-3072
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 44,209,1991
 
                            *** END OF RECORD ***