*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DE5414000
CHEMICAL NAME           : Benzo(h)(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,12-d
                          ione, 10-((2-o-(2-amino-2,6-dideoxy-3-
                          o-methyl-alpha-D-galactopyranosyl)-6-deoxy-3-C-methyl
                          -beta-D-galactopyrano syl)oxy)-6- hydroxy-1-methyl-,
                          butanedioate
LAST UPDATED            : 199509
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C33-H35-N-O13.C4-H6-O4
MOLECULAR WEIGHT        : 771.79
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Elsamicin succinate salt
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Vascular - shock
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 8,85,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16300 mg/kg
TOXIC EFFECTS :
   Vascular - shock
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 8,85,1988
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 160 ug/kg
TOXIC EFFECTS :
   Vascular - shock
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 8,85,1988
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20 mg/kg/5D-I
TOXIC EFFECTS :
   Blood - other changes
   Blood - changes in other cell count (unspecified)
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 8,85,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 350 ug/kg/5D-I
TOXIC EFFECTS :
   Blood - changes in other cell count (unspecified)
   Blood - changes in leukocyte (WBC) count
   Related to Chronic Data - death
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 8,85,1988
 
                            *** END OF RECORD ***