*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : DD6495000
CHEMICAL NAME : 2-Benzimidazolecarbamic acid, 5-butyl-, methyl ester
CAS REGISTRY NUMBER : 14255-87-9
LAST UPDATED : 199306
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C13-H17-N3-O2
MOLECULAR WEIGHT : 247.33
WISWESSER LINE NOTATION : T56 BM DNJ CMVO1 G4
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 5-Butyl-2-benzimidazolecarbamic acid methyl ester
* N-(Butyl-5, benzimidazolyl)-2, carbamate de methyle
* (4-Butyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester
* 5-Butyl-2-(carbomethoxyamino)benzimidazole
* Carbamic acid, (5-butyl-1H-benzimidazol-2-yl)-, methyl ester
* Helmatac
* Methyl 5-butyl-2-benzimidazolecarbamate
* Parbendazole
* PBDZ
* SKF 29044
* Verminum
* Worm Guard
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3657267
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981.
Volume(issue)/page/year: 77,379,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : >40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3657267
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - domestic
DOSE/DURATION : 660 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc.,
Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2-
1927- Volume(issue)/page/year: 46,297,1970
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - cattle
DOSE/DURATION : >1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc.,
Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2-
1927- Volume(issue)/page/year: 46,297,1970
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - cattle
DOSE/DURATION : 450 mg/kg/6D-I
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc.,
Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2-
1927- Volume(issue)/page/year: 46,297,1970
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1200 mg/kg
SEX/DURATION : female 7-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
REFERENCE :
BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981.
Volume(issue)/page/year: 75,117,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 80 mg/kg
SEX/DURATION : female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 31,505,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 80 mg/kg
SEX/DURATION : female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 31,505,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 150 mg/kg
SEX/DURATION : female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
RMVEAG Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year Book
Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824-
Volume(issue)/page/year: 152,467,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 80 mg/kg
SEX/DURATION : female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981.
Volume(issue)/page/year: 76,147,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 4 gm/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system
REFERENCE :
BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981.
Volume(issue)/page/year: 75,309,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 90 mg/kg
SEX/DURATION : female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 31,491,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 400 mg/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981.
Volume(issue)/page/year: 77,379,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 10 gm/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981.
Volume(issue)/page/year: 75,309,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 16 gm/kg
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
BSVMA8 Bulletin de la Societe des Sciences Veterinaires et de Medecine
Comparee de Lyon. (Lyons, France) V.1-83, 1898-1981.
Volume(issue)/page/year: 75,309,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 130 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
COVEAZ Cornell Veterinarian. (Cornell Univ. New York State College of
Veterinary Medicine, Ithaca, NY 14853) V.1- 1911-
Volume(issue)/page/year: 64(Suppl 4),104,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE : 780 mg/kg
SEX/DURATION : female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
COVEAZ Cornell Veterinarian. (Cornell Univ. New York State College of
Veterinary Medicine, Ithaca, NY 14853) V.1- 1911-
Volume(issue)/page/year: 64(Suppl 4),104,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - domestic
DOSE : 60 mg/kg
SEX/DURATION : female 21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - physical
REFERENCE :
COVEAZ Cornell Veterinarian. (Cornell Univ. New York State College of
Veterinary Medicine, Ithaca, NY 14853) V.1- 1911-
Volume(issue)/page/year: 64(Suppl 4),41,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - domestic
DOSE : 30 mg/kg
SEX/DURATION : female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
COVEAZ Cornell Veterinarian. (Cornell Univ. New York State College of
Veterinary Medicine, Ithaca, NY 14853) V.1- 1911-
Volume(issue)/page/year: 64(Suppl 4),56,1974
** MUTATION DATA **
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 2,67,1980
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 1 mg/L
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 31,505,1976
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Mammal - domestic Leukocyte
DOSE/DURATION : 1 mg/L
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 31,505,1976
*** END OF RECORD ***