*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DD1751000
CHEMICAL NAME           : Benzidine, 2,2',5,5'-tetrachloro-
CAS REGISTRY NUMBER     : 15721-02-5
BEILSTEIN REFERENCE NO. : 3364286
REFERENCE               : 3-13-00-00447 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C12-H8-Cl4-N2
MOLECULAR WEIGHT        : 322.02
WISWESSER LINE NOTATION : ZR BG EG DR DZ CG FG
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * (1,1'-Biphenyl)-4,4'-diamine, 2,2',5,5'-tetrachloro-
   * Tetrachlorobenzidine
   * 2,2',5,5'-Tetrachlorobenzidine
   * 3,3',6,6'-Tetrachlorobenzidine
   * 2,2',5,5'-Tetrachloro-(1,1'-biphenyl)-4,4'-diamine
   * 2,2',5,5'-Tetrachloro-4,4'-diaminodiphenyl
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 54 mg/kg/43W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   JMEJAS Jikeikai Medical Journal.  (Jikei Univ. School of Medicine, 3-25-8
   Nishi-shinbashi, Minato-ku, Tokyo 105, Japan)  V.1-    1954-
   Volume(issue)/page/year: 25,123,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36 mg/kg/43W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   JMEJAS Jikeikai Medical Journal.  (Jikei Univ. School of Medicine, 3-25-8
   Nishi-shinbashi, Minato-ku, Tokyo 105, Japan)  V.1-    1954-
   Volume(issue)/page/year: 25,123,1978
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 gm/kg/43W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,141,1982
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 900 gm/kg/43W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,141,1982

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,141,1982

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,141,1982

   IARC Cancer Review:Group 3
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***