*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DC8442000
CHEMICAL NAME           : Benzhydrol, alpha-(2-(dimethylamino)-1-methylethyl)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 7405-15-4
LAST UPDATED            : 199012
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C18-H23-N-O.Cl-H
MOLECULAR WEIGHT        : 305.88
WISWESSER LINE NOTATION : QXR&R&Y1&1N1&1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * alpha-(2-(Dimethylamino)-1-methylethyl)benzhydrol hydrochloride
   * 1,1-Diphenyl-2-methyl-3-(dimethylamino)propanol hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 14,1106,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 325 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 98,121,1950
 
                            *** END OF RECORD ***