*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DC2050000
CHEMICAL NAME           : 1,2,4-Benzenetricarboxylic acid 1,2-anhydride
CAS REGISTRY NUMBER     : 552-30-7
BEILSTEIN REFERENCE NO. : 0009394
REFERENCE               : 5-18-08-00562 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 25
MOLECULAR FORMULA       : C9-H4-O5
MOLECULAR WEIGHT        : 192.13
WISWESSER LINE NOTATION : T56 BVOVJ GVQ
SYNONYMS/TRADE NAMES :
   * Anhydrotrimellic acid
   * 1,2,4-Benzenetricarboxylic acid anhydride
   * 1,2,4-Benzenetricarboxylic acid, cyclic 1,2-anhydride
   * 1,2,4-Benzenetricarboxylic anhydride
   * 4-Carboxyphthalic anhydride
   * 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid
   * 1,3-Dioxo-5-phthalancarboxylic acid
   * Diphenylmethane-4,4'-diisocyanate-trimellic anhydride-ethomid HT polymer
   * Epon 9150
   * NCI-C56633
   * 5-Phthalanacarboxylic acid, 1,3-dioxo-
   * Trimellic acid anhydride
   * Trimellic acid 1,2-anhydride
   * Trimellitic acid cyclic 1,2-anhydride
   * Trimellitic anhydride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >7400 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
   Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
   Industrial Hygienists, Inc., 1986  Volume(issue)/page/year: 6,1642,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1900 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 18(7),57,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
   Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
   Industrial Hygienists, Inc., 1986  Volume(issue)/page/year: 6,1642,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 258 ug/m3/6H/10D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
   Lungs, Thorax, or Respiration - other changes
   Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   87,67,1987

                              *** REVIEWS ***
 
   ACGIH TLV-CL 0.04 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   TOXICOLOGY REVIEW
   BPCT** Progress Report from the Environmental Protection Agency to NIOSH on
   Benzenepolycarboxylates, 1974  Volume(issue)/page/year: -,183,1974

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 0.005 ppm (0.04 mg/m3) JAN 1993
   
   OEL-BELGIUM:TWA 0.005 ppm (0.059 mg/m3) JAN 1993
   
   OEL-DENMARK:TWA 0.1 mg/m3 JAN 1993
   
   OEL-FRANCE:TWA 0.005 ppm (0.04 mg/m3) JAN 1993
   
   OEL-GERMANY:TWA 0.005 ppm (0.04 mg/m3) JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.004 ppm (0.04 mg/m3) JAN 1993
   
   OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.005 ppm (0.04 mg/m3) JAN 1993
   
   OEL-SWITZERLAND:TWA 0.005 ppm (0.04 mg/m3);STEL 0.01 ppm JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.04 mg/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO TRIMELLITIC ANHYDRIDE-air:10H TWA 0.005 ppm
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83588
       No. of Facilities: 196 (estimated)
       No. of Industries: 8
       No. of Occupations: 31
       No. of Employees: 11308 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83588
       No. of Facilities: 358 (estimated)
       No. of Industries: 9
       No. of Occupations: 13
       No. of Employees: 17745 (estimated)
       No. of Female Employees: 5236 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NIOSH CURRENT INTELLIGENCE BULLETIN 21, 1978
   
   NIOSH Analytical Method, 1994: Trimellitic anhydride, 5036

 
                            *** END OF RECORD ***