RTECS NUMBER-DB1290000-Chemical Toxicity Database

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DB1290000
CHEMICAL NAME           : Benzenesulfonamide,
                          N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-
CAS REGISTRY NUMBER     : 1492-02-0
BEILSTEIN REFERENCE NO. : 1082473
LAST UPDATED            : 199612
DATA ITEMS CITED        : 13
MOLECULAR FORMULA       : C12-H15-N3-O2-S2
MOLECULAR WEIGHT        : 297.42
WISWESSER LINE NOTATION : T5NN DSJ CX1&1&1 EMSWR
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * AN 1324
   * 2-Benzenesulfonamido-5-tert-butyl-1,3,4-thiadiazole
   * 2-Benzenesulfonamido-5-tertiobutyl-1-thia-3,4-diazole
   * N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
   * Desaglybuzole
   * Gludiase
   * Glybuzole
   * RP 7891
   * TH-1395
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 219 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Endocrine - hypoglycemia
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 3,131,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 235 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 248 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 193 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 967 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 118 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1050 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   YIKUAO Yamaguchi Igaku.  Yamaguchi Medicine.  (Yamaguchi Daigaku Igakkai,
   Kogushi Ube, Yamaguchi- Ken, Japan)  V.1-    1953- Volume(issue)/page/year:
   18,21,1969
 
                            *** END OF RECORD ***