*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DA9500000
CHEMICAL NAME           : Benzenesulfonamide,
                          4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-
CAS REGISTRY NUMBER     : 2447-57-6
BEILSTEIN REFERENCE NO. : 0625453
REFERENCE               : 5-25-13-00306 (Beilstein Handbook Reference)
LAST UPDATED            : 199703
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C12-H14-N4-O4-S
MOLECULAR WEIGHT        : 310.36
WISWESSER LINE NOTATION : T6N CNJ DO1 EO1 FMSWR DZ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 6-(4-Aminobenzenesulfonamido)-4,5-dimethoxypyrimidine
   * 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
   * N'-(5,6-Dimethoxy-4-pyrimidyl)sulfanilamide
   * Fanasil
   * Fanzil
   * Ro 4-4393
   * Sulfadoxine
   * 4-Sulfanilamido-5,6-dimethoxypyrimidine
   * Sulforthomidine
   * Sulphormethoxine
   * WR 4873
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 14,195,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 14,195,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 14,195,1969
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 14,37,1969
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 44 gm/kg/15D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 14,195,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 18 gm/kg/26W-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Related to Chronic Data - death
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 14,195,1969
 
                            *** END OF RECORD ***