*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DA4172750
CHEMICAL NAME           : Benzenepropanoic acid,
                          beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydr
                          oxy-,
                          12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11
                          ,12,12a,12b-dodecahyd ro-4,6,11-
                          trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-
                          1H-cyclodeca(3,4)benz (1,2-b)oxet-9-yl ester,
                          (2aR-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alpha-R*
                          ,beta-S*),11-alpha,12 -alpha,12a- alpha,12b-alpha))-
CAS REGISTRY NUMBER     : 114977-28-5
LAST UPDATED            : 199512
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C43-H53-N-O14
MOLECULAR WEIGHT        : 807.97
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Docetaxel
   * Docetaxol
   * RP 56976
   * Taxotere
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 156 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SOLGAV Seminars in Oncology.  (Grune & Stratton Inc., Journal Subscription
   Dept., POB 6280, Duluth, MN 55806)  V.1-    1974-  Volume(issue)/page/year:
   22(Suppl 4),3,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SOLGAV Seminars in Oncology.  (Grune & Stratton Inc., Journal Subscription
   Dept., POB 6280, Duluth, MN 55806)  V.1-    1974-  Volume(issue)/page/year:
   22(Suppl 4),3,1995
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 40800 ug/kg/33W-I
TOXIC EFFECTS :
   Blood - leukopenia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 15,71,1995
 
                            *** END OF RECORD ***