*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CZ1582000
CHEMICAL NAME           : 1,4-Benzenediamine, 2,6-dichloro-N(sup
                          1)-(4,5-dihydro-1H-imidazol-2-yl)-, monohydrochloride
CAS REGISTRY NUMBER     : 73218-79-8
LAST UPDATED            : 199604
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C9-H10-Cl2-N4.Cl-H
MOLECULAR WEIGHT        : 281.59
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * ALO-2145
   * p-Aminoclonidine hydrochloride
   * 2-(4-Amino-2,6-dichlorophenylimino)imidazolidine hydrochloride
   * Apraclonidine hydrochloride
   * 2,6-Dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine  
   monohydrochloride
   * 2,6-Dichloro-N(sup 1)-(2-imidazolidinylidene)-1,4-benzenediamine  
   hydrochloride
   * 3,5-Dichloro-4-(2-imidazolidinylidenimino)aniline hydrochloride
   * Iopidine
   * Iopidine ophthalmic solution
   * NC 14 hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   24,557,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   24,557,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   24,557,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   24,557,1988
 
                            *** END OF RECORD ***