*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AE6125000
CHEMICAL NAME           : Acetanilide, 4'-phenyl-
CAS REGISTRY NUMBER     : 4075-79-0
BEILSTEIN REFERENCE NO. : 2097736
REFERENCE               : 4-12-00-03248 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C14-H13-N-O
MOLECULAR WEIGHT        : 211.28
WISWESSER LINE NOTATION : 1VMR DR
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acetamide, N-(1,1'-biphenyl)-4-yl-
   * 4-Acetamidobiphenyl
   * 4-Acetylaminobiphenyl
   * N-Acetylxenylamin
   * 4-Biphenylacetamide
   * N-4-Biphenylacetamide
   * N-(4-Biphenylyl)acetamide
   * N-(1,1'-Biphenyl)-4-ylacetamide
   * 4'-Fenylacetanilid
   * p-Phenylacetanilide
   * 4'-Phenylacetanilide
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2770 mg/kg/21W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   15,188,1955
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 13 gm/kg/3Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   23,921,1963
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4070 mg/kg/34W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   16,525,1956
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3425 mg/kg/26W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   22,1002,1962
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2240 mg/kg/16W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   21,1465,1961
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 175,11,1986

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   ADCSAJ Advances in Chemistry Series.  (American Chemical Soc., Distribution
   Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037)  No.1-
   1950-  Volume(issue)/page/year: 13,271,1970

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***