*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AE2100000
CHEMICAL NAME           : Acetanilide, 2-(diethylamino)-2',4',6'-trimethyl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 1027-14-1
LAST UPDATED            : 199603
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C15-H24-N2-O.Cl-H
MOLECULAR WEIGHT        : 284.87
WISWESSER LINE NOTATION : 2N2&1VMR B1 D1 F1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Acetamide, 2-(diethylamino)-N-(2,4,6-trimethylphenyl)-, monohydrochloride
   * Acetanilide, 2-(diethylamino)-2',4',6'-trimethyl-, monohydrochloride
   * Diethylaminoacetyl 2,4,6-trimethyl-aniline hydrochloride
   * 2-Diethylamino-2',4',6'-trimethylacetanilide hydrochloride
   * Mesidicaine hydrochloride
   * Mesocain
   * Mesocaine
   * Mesokain
   * Trimecaine hydrochloride
   * Trimekain hydrochloride
   * N-sym-Trimethylphenyldiethylaminoacetamide hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 172 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AFPCAG Acta Facultatis Pharmaceuticae, Universitatis Comenianae.  (Ustredna
   Kniznica Farmaceuticka Fakulta Univerzity Komenskeho, Sasinkova 5, 886 34
   Bratislava, Czechoslovakia)  V.14-    1967-  Volume(issue)/page/year:
   29,81,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 295 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:
   11,1526,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 25,731,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DMDIEQ Drug Metabolism and Drug Interactions.  (Freund Publishing House,
   Suite 500, Chesham House, 150 Regent Street, London, W1R 5FA, United
   Kingdom)  V.6-    1988-  Volume(issue)/page/year: 9,321,1991
 
                            *** END OF RECORD ***