*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : AC8450000
CHEMICAL NAME : Acetamide, N-sulfanilyl-
CAS REGISTRY NUMBER : 144-80-9
BEILSTEIN REFERENCE NO. : 0981718
REFERENCE : 4-14-00-02662 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 14
MOLECULAR FORMULA : C8-H10-N2-O3-S
MOLECULAR WEIGHT : 214.26
WISWESSER LINE NOTATION : ZR DSWMV1
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* A-500
* Acetamide, N-((4-aminophenyl)sulfonyl)-
* Acetocid
* Acetosulfamin
* Acetosulfamine
* N-Acetyl-4-aminobenzenesulfonamide
* N(sup 1)-Acetyl-4-aminophenylsulfonamide
* N-Acetylsulfanilamide
* N'-Acetylsulfanilamide
* N(sup 1)-Acetylsulfanilamide
* N-Acetylsulfanilamine
* Albamine
* Albucid
* Alesten
* p-Aminobenzenesulfonacetamide
* p-Aminobenzenesulfonoacetamide
* N-((4-Aminophenyl)sulfonyl)acetamide
* Bleph-10
* Bleph-10 liquifilm
* Formosulfacetamide
* Isopto cetamide
* Ophthel-S
* OP-Sulfa 30
* Region
* Sebizon
* Steramide
* Sulamyd
* Sulf-10
* Sulfacet
* Sulfacetamide
* Sulfacetimide
* Sulfacyl
* Sulfanilacetamide
* Sulfanilamide, N(sup 1)-acetyl-
* Sulfanilazetamid
* N-Sulfanilylacetamide
* Sulphacetamide
* Sulphasil
* Urosulfon
* Urosulfone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 6600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 211,367,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 16500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 47,183,1942
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 606 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.3- 1930- Volume(issue)/page/year: (6),26,1987
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 8 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - rigidity (including catalepsy)
REFERENCE :
JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 47,183,1942
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 47,183,1942
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 10 gm/kg
SEX/DURATION : female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
PROEAS Problemy Endokrinologii. Problems of Endocrinology. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-6, 1936-41; 13- 1967-
Volume(issue)/page/year: 14,89,1968
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 250 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 167,35,1986
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 2 gm/L
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 31,97,1979
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1 gm/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
10(Suppl 10),1,1987
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80537
No. of Facilities: 68 (estimated)
No. of Industries: 1
No. of Occupations: 6
No. of Employees: 2770 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80537
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 1639 (estimated)
No. of Female Employees: 1344 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: N crassa-aneuploidy; S
cerevisiae-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***