*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CX3075000
CHEMICAL NAME           : Benz(a)anthracene,
                          8,9,10,11-tetrahydro-8-beta,9-alpha-dihydroxy-10-beta
                          ,11-beta-epoxy-, (E)-(+-)-
CAS REGISTRY NUMBER     : 64598-82-9
LAST UPDATED            : 199503
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C18-H14-O3
MOLECULAR WEIGHT        : 278.32
WISWESSER LINE NOTATION : T E3 D6 B666 FOTT&&&J HQ IQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   *   (+,-)-trans-8beta,9alpha-Dihydroxy-10beta,11beta-epoxy-8,9,10,11-tetrahy
     drobenz(a)anthracene
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,1699,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 44,313,1977
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 600 ug/L
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   39,540,1979

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation

 
                            *** END OF RECORD ***