*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CY1576890
CHEMICAL NAME           : Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-,
                          (4-diethylamino)-1,1-dimethyl- 2-buteynyl ester,
                          hydrochloride
CAS REGISTRY NUMBER     : 129927-33-9
OTHER CAS REGISTRY NOS. : 136529-33-4
LAST UPDATED            : 199712
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C24-H35-N-O3.Cl-H
MOLECULAR WEIGHT        : 422.06
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * (+-)-4-Diethylamino-1,1-dimethylbut-2-yn-1-yl  
   2-cyclohexyl-2-hydroxy-2-phenylacetate HCl H2O
   * NS-21
   * Urespan
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 gm/kg
SEX/DURATION            : male 60 day(s) pre-mating
                          female 14 day(s) pre-mating  - 7 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 22(Suppl
   1),201,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 8100 mg/kg
SEX/DURATION            : female 17-21 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 22(Suppl
   1),239,1997
 
                            *** END OF RECORD ***