*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CW1795500
CHEMICAL NAME           : Benz(a)anthracene,
                          3,4-dihydro-3,4-dihydroxy-7,12-dimethyl-, (E)-
CAS REGISTRY NUMBER     : 68162-13-0
BEILSTEIN REFERENCE NO. : 4500017
LAST UPDATED            : 199612
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C20-H18-O2
MOLECULAR WEIGHT        : 290.38
WISWESSER LINE NOTATION : L D6 B666 QU&&&TJ C1 J1 OQ PQ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz(a)anthracene
   * trans-3,4-Dihydro-3,4-dihydroxy-dmba
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 105 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,1934,1979
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 34846 ng/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,3661,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 3 nmol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,3661,1980
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 120 ug/L
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 85,357,1978
 
TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1161 pg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 7,535,1986
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 ug/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   7,45,1979
 
TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 120 ug/L/3H
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   39,540,1979

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse prostate
   
   EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
   
   EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat

 
                            *** END OF RECORD ***