*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV6580000
CHEMICAL NAME           : Benzamidine, 4,4'-(trimethylenedioxy)di-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 6275-69-0
LAST UPDATED            : 199009
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C17-H20-N4-O2.2Cl-H
MOLECULAR WEIGHT        : 385.33
WISWESSER LINE NOTATION : MUYZR DO3OR DYZUM &GH 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzenecarboximidamide, 4,4'-(1,3-propanediylbis(oxy))bis-,  
   dihydrochloride
   * 4,4'-Diamidino-alpha,gamma-diphenoxypropane dihydrochloride
   * 4,4'-Diamidino-1,3-diphenoxypropane dihydrochloride
   * M & B 782 dihydrochloride
   * Panamidin dihydrochloride
   * Propamidine dihydrochloride
   * 4,4'-(Trimethylenedioxy)dibenzamidine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   ANTCAO Antibiotics and Chemotherapy (Washington, DC).  (Washington, DC)
   V.1-12, 1951-62.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 2,581,1952
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ATMPA2 Annals of Tropical Medicine and Parasitology.  (Grune & Stratton,
   Inc., POB 6280, Duluth, MN 55806)  V.1-    1907-  Volume(issue)/page/year:
   37,1,1943
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35100 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   ANTCAO Antibiotics and Chemotherapy (Washington, DC).  (Washington, DC)
   V.1-12, 1951-62.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 2,581,1952
 
                            *** END OF RECORD ***