*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV6550000
CHEMICAL NAME           : Benzamidine, 4-propoxy-N-(2-(1-pyrrolidinyl)ethyl)-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 62979-92-4
LAST UPDATED            : 199109
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C16-H25-N3-O.2Cl-H
MOLECULAR WEIGHT        : 348.36
WISWESSER LINE NOTATION : T5NTJ A2MYUM&R DO3
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzenecarboximidamide, 4-propoxy-N-(2-(1-pyrrolidinyl)ethyl)-,  
   dichloride
   * PPR 497
   * 4-Propoxy-N-(2-pyrrolidinylethyl)benzamidine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 32,501,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 185 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 11,513,1976
 
                            *** END OF RECORD ***