*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV6475000
CHEMICAL NAME           : Benzamidine, 4,4'-(pentamethylenedioxy)di-
CAS REGISTRY NUMBER     : 100-33-4
BEILSTEIN REFERENCE NO. : 3159790
REFERENCE               : 4-10-00-00447 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C19-H24-N4-O2
MOLECULAR WEIGHT        : 340.47
WISWESSER LINE NOTATION : MUYZR DO5OR DYZUM
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-
   * 4,4'-Diamidinodiphenoxypentane
   * 4,4'-Diamidino-alpha,omega-diphenoxypentane
   * p,p'-(Pentamethylene-dioxy)bis-benzamidine
   * p,p'-(Pentamethylenedioxy)dibenzamidine
   * 4,4'-(Pentamethylenedioxy)dibenzamidine
   * Pentamidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 28 mg/kg/1W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 145,2247,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 4 mg/kg/3D
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 246,338,1944
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Endocrine - hypoglycemia
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   99,128,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,794,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSCFAS Bulletin de la Societe Chimique de France.  (CDR-Centrale des Revues,
   11, rue Gossin, F-92543 Montrouge Cedex, France)  V.1-    1864-
   Volume(issue)/page/year: -,376,1968
 
                            *** END OF RECORD ***