*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV4903000
CHEMICAL NAME           : Benzamide, 2-ethoxy-, mixt. with
                          1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3
                          H- pyrazol-3-one and
                          3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
                          hydrate (3:5:1)
CAS REGISTRY NUMBER     : 82464-70-8
LAST UPDATED            : 198403
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C14-H18-N2-O.C9-H11-N-O2.C8-H10-N4-O2.H2-O
MOLECULAR WEIGHT        : 607.79
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Isopropylantipyrine mixed with ethenzamide and caffeine monohydrate  
   (3:5:1)
   * Ro 04-7683
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 10,1407,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 405 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 10,1407,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 10,1407,1982
 
                            *** END OF RECORD ***