*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV5521000
CHEMICAL NAME           : Benzamide,
                          4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)pheny
                          l)-, (+-)-
CAS REGISTRY NUMBER     : 66778-36-7
BEILSTEIN REFERENCE NO. : 0497572
REFERENCE               : 5-22-09-00511 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C22-H28-N2-O2
MOLECULAR WEIGHT        : 352.52
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Encainide
   * (+-)-4-Methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide
   * MJ 9067
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 3289 ug/kg
TOXIC EFFECTS :
   Cardiac - arrhythmias (including changes in conduction)
   Cardiac - change in rate
REFERENCE :
   AEMED3 Annals of Emergency Medicine.  (American College of Emergency
   Physicians, 1125 Executive Circle, Irving, TX 75038)
   Volume(issue)/page/year: 21,998,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 43 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   AJCDAG American Journal of Cardiology.  (Technical Pub. Co., 875 Third Ave.,
   New York, NY 10022) V.1-    1958-  Volume(issue)/page/year: 57,878,1986
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 3214 mg/kg/19H
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
   Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
   AHJOA2 American Heart Journal.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63146) V.1-    1925-  Volume(issue)/page/year:
   102,857,1981
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2400 ug/kg/17H
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
   Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
   AHJOA2 American Heart Journal.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63146) V.1-    1925-  Volume(issue)/page/year:
   102,857,1981
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1500 ug/kg
TOXIC EFFECTS :
   Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
   AHJOA2 American Heart Journal.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63146) V.1-    1925-  Volume(issue)/page/year:
   102,857,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 38100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 281,277,1986
 
                            *** END OF RECORD ***