*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV5376200
CHEMICAL NAME           : Benzamide,
                          2-hydroxy-N-((4-hydroxy-1-phenethyl-4-piperidinyl)met
                          hyl)-, monohydrochloride
CAS REGISTRY NUMBER     : 25552-58-3
LAST UPDATED            : 199112
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C21-H26-N2-O3.Cl-H
MOLECULAR WEIGHT        : 390.95
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2-Hydroxy-N-((4-hydroxy-1-phenethyl-4-piperidinyl)methyl)benzamide  
   hydrochloride
   * 1-Phenaethyl-4-hydroxy-salicylamido-4-methyl-piperidin-hydrochlorid
   * Phenethyl-1 hydroxy-4 salicylamido methyl-4 piperidine chlorhydrate
   * 1-Phenethyl-4-hydroxysalicylamido-4-methylpiperidine hydrochloride
   * S 1592
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,516,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 157 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - irritability
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,516,1976
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,516,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 251 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - irritability
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,516,1976
 
                            *** END OF RECORD ***