*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV4285000
CHEMICAL NAME           : Benzamide,
                          N-((diethylcarbamoyl)methyl)-3,4,5-trimethoxy-
CAS REGISTRY NUMBER     : 363-20-2
BEILSTEIN REFERENCE NO. : 2708816
REFERENCE               : 4-10-00-02022 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C16-H24-N2-O5
MOLECULAR WEIGHT        : 324.42
WISWESSER LINE NOTATION : 2N2&V1MVR CO1 DO1 EO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzamide, N-(2-(diethylamino)-2-oxoethyl)-3,4,5-trimethoxy-
   * N-((Diethylcarbamoyl)methyl)-3,4,5-trimethoxybenzamide
   * R-548
   * Riker 548
   * Tricetamide
   * Trimeglamide
   * N-(3,4,5-Trimethoxybenzoyl)glycine diethylamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 340 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 137,218,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   17,351,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 86,120,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,380,1972
 
                            *** END OF RECORD ***