*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV2462000
CHEMICAL NAME           : Benzamide, 4-chloro-N-(2-(4-morpholinyl)ethyl)-
CAS REGISTRY NUMBER     : 71320-77-9
BEILSTEIN REFERENCE NO. : 0530974
LAST UPDATED            : 199803
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C13-H17-Cl-N2-O2
MOLECULAR WEIGHT        : 268.77
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Aurorix
   * 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide
   * Moclobemide
   * Ro 11-1163
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 5 mg/kg/5W-I
TOXIC EFFECTS :
   Skin and Appendages - hair
REFERENCE :
   HUPSEC Human Psychopharmacology.  (John Wiley & Sons Ltd., Baffins Lane,
   Chichester, W.Sussex PO19 1UD, United Kingdom)  V.1-    1986-
   Volume(issue)/page/year: 12,81,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - hallucinations, distorted perceptions
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/year: 47,438,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 66 mg/kg/11D-I
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 346,1032,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 12600 mg/kg/14D-I
TOXIC EFFECTS :
   Blood - thrombocytopenia
   Blood - leukemia
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 347,1329,1996
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 707 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4210754
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 591 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 31,909,1996
 
                            *** END OF RECORD ***