*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CV2451300
CHEMICAL NAME           : Benzamide,
                          4-chloro-N-(2-alpha-methyl-1-indolinyl)-3-sulfamoyl-,
                          S-(+)-
LAST UPDATED            : 198506
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C16-H16-Cl-N3-O3-S
MOLECULAR WEIGHT        : 365.86
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * S-(+)-4-Chloro-N-(2-alpha-methyl-1-indolinyl)-3-sulfamoylbenzamide
   * S-(+)-Indapamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 16,2275,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 860 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 16,2275,1982
 
                            *** END OF RECORD ***