*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CU3490000
CHEMICAL NAME           : Benz(c)acridine, 7,11-dimethyl-
CAS REGISTRY NUMBER     : 32740-01-5
BEILSTEIN REFERENCE NO. : 0200567
REFERENCE               : 5-20-08-00539 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H15-N
MOLECULAR WEIGHT        : 257.35
WISWESSER LINE NOTATION : T D6 B666 CNJ E1 J1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1,10-Dimethyl-7,8-benzacridine
   * 7,11-Dimethylbenz(c)acridine
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 360 mg/kg/30W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Lungs, Thorax, or Respiration - bronchiolar constriction
REFERENCE :
   ACRSAJ Advances in Cancer Research.  (Academic Press, Inc., 465 S. Lincoln
   Dr., Troy, MO 63379) V.1-    1953-  Volume(issue)/page/year: 4,315,1956
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg/4W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   ACRSAJ Advances in Cancer Research.  (Academic Press, Inc., 465 S. Lincoln
   Dr., Troy, MO 63379) V.1-    1953-  Volume(issue)/page/year: 4,315,1956
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg/10D-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer.  (Paris,
   France)  V.1-52, 1908-65. For publisher information, see BUCABS.
   Volume(issue)/page/year: 34,22,1947
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 nmol/plate
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   70,749,1979
 
                            *** END OF RECORD ***