*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CU3440000
CHEMICAL NAME           : Benz(c)acridine,
                          7-(2-(2-chloroethylethylamino)ethylamino)-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 4310-69-4
LAST UPDATED            : 199109
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C23-H24-Cl-N3.2Cl-H
MOLECULAR WEIGHT        : 450.87
WISWESSER LINE NOTATION : T D6 C666 BNJ MM2N2&2G &GH 2
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
SYNONYMS/TRADE NAMES :
   * 1,2-Ethanediamine, N'-benz(c)acridin-7-yl-N-(2-chloroethyl)-N-ethyl-,  
   dihydrochloride
   * 7-(2-(Ethyl-2-chloroethyl)aminoethylamino)benz(c)acridine dihydrochloride
   * ICR 311
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD20 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3823 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,2423,1976
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   36,2423,1976
 
                            *** END OF RECORD ***