*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CO1741500
CHEMICAL NAME           : 8-Azoniabicyclo(3.2.1)octane,
                          3-(benzoyloxy)-8-((4-cyclohexylphenyl)methyl)-8-methy
                          l-, bromide, (endo,syn)-
CAS REGISTRY NUMBER     : 1107-17-1
LAST UPDATED            : 198909
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C28-H36-N-O2.Br
MOLECULAR WEIGHT        : 498.56
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 8-(p-Cyclohexylbenzyl)-8-methylnortropinium bromide benzoate
   * N 718
   * 1-alpha-H,5-alpha-H-Tropanium, 8-(p-cyclohexylbenzyl)-3-alpha-hydroxy-,  
   bromide, benzoate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 21,10,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22700 ug/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 21,10,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 21,10,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 33 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 21,10,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 47 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 21,10,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21600 ug/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 21,10,1963
 
                            *** END OF RECORD ***