*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CO1651000
CHEMICAL NAME           : 8-Azoniabicyclo(3.2.1)heptane,
                          8-((4-cyclohexylphenyl)methyl)-8-methyl-3-((4-methylb
                          enzoyl) oxy)-, bromide, endo-
CAS REGISTRY NUMBER     : 3564-36-1
LAST UPDATED            : 198909
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C29-H38-N-O2.Br
MOLECULAR WEIGHT        : 512.59
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 8-(p-Cyclohexylbenzyl)tropinium bromide p-toluate
   * N 856
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 990 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 21,10,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51900 ug/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 21,10,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 21,10,1963
 
                            *** END OF RECORD ***