*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CN1068000
CHEMICAL NAME           : Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione,
                          1,1a,2,8,8a,8b-hexahydro-8-
                          (hydroxymethyl)-8a-methoxy-5-methyl-6-propoxy-,
                          carbamate
CAS REGISTRY NUMBER     : 56981-60-3
LAST UPDATED            : 198606
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C18-H23-N3-O6
MOLECULAR WEIGHT        : 377.44
WISWESSER LINE NOTATION : T D3 B556 BN EM JV MVTTT&J GO1 H1OVZ KO3 L1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 9-(Hydroxymethyl)-9a-methoxy-6-methyl-7-propoxymitosane carbamate
   * 7-Propoxy-7-demethoxymitomycin A
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3350 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 33,804,1980
 
                            *** END OF RECORD ***