*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CN0875000
CHEMICAL NAME           : Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione,
                          1,1a,2,8,8a,8b-hexahydro-8a-hydroxy-8-
                          (hydroxymethyl)-6-methoxy-1,5-dimethyl-, 8-carbamate
CAS REGISTRY NUMBER     : 4055-40-7
LAST UPDATED            : 199806
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C16-H19-N3-O6
MOLECULAR WEIGHT        : 349.38
WISWESSER LINE NOTATION : T D3 B556 BN EN JV MVTTT&J E1 GQ H1OVZ KO1 L1
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Mitomycin B
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 36,1461,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 14,103,1971
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 60 umol/L
REFERENCE :
   CJBIAE Canadian Journal of Biochemistry.  (Ontario, Canada)  V.42-60,
   1964-82.  For publisher information, see CJBBDU.  Volume(issue)/page/year:
   56,296,1978
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mg/L
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 14,103,1971
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 60 umol/L
REFERENCE :
   CJBIAE Canadian Journal of Biochemistry.  (Ontario, Canada)  V.42-60,
   1964-82.  For publisher information, see CJBBDU.  Volume(issue)/page/year:
   56,296,1978
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Protozoa - Euglena gracilis
DOSE/DURATION           : 50 mg/L
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 19,579,1972
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Protozoa - Euglena gracilis
DOSE/DURATION           : 50 mg/L
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 19,579,1972
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 60 umol/L
REFERENCE :
   CJBIAE Canadian Journal of Biochemistry.  (Ontario, Canada)  V.42-60,
   1964-82.  For publisher information, see CJBBDU.  Volume(issue)/page/year:
   56,296,1978
 
                            *** END OF RECORD ***