*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CO9450000
CHEMICAL NAME           : Bacillus subtilis bpn
CAS REGISTRY NUMBER     : 1395-21-7
LAST UPDATED            : 199712
DATA ITEMS CITED        : 8
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Bacillomycin
   * Bacillomycin R
   * Fungocin
   * Subtilisin
   * Subtilisin BPN
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3 mg
REACTION SEVERITY       : Severe
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 7,581,1969
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 3,1606,1978

                              *** REVIEWS ***
 
   ACGIH TLV-CL 0.00006 mg/m3, high-volume sampling
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 0.00006 mg/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 0.00006 mg/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.00006 mg/m3;STEL 0.00006 mg/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

 
                            *** END OF RECORD ***