*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CO4826000
CHEMICAL NAME           : 1-Azulenesulfonic acid, 5-isopropyl-3,8-dimethyl-,
                          sodium salt
CAS REGISTRY NUMBER     : 6223-35-4
OTHER CAS REGISTRY NOS. : 36905-16-5
LAST UPDATED            : 199806
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C15-H18-O3-S.Na
MOLECULAR WEIGHT        : 301.38
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-Azulenesulfonic acid, 3,8-dimethyl-5-(1-methylethyl)-, sodium salt
   * Azulen SN
   * Azupromin
   * Sodium guaiazulene-3-sulfonate
   * Sodium 7-isopropyl-1,4-dimethylazulene-3-sulfonate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 19,615,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   SHNSAS Shinryo to Shinyaku.  Medical Consultation and New Remedies.  (Iji
   Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan)  V.1-    1964-
   Volume(issue)/page/year: 11,2533,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   SHNSAS Shinryo to Shinyaku.  Medical Consultation and New Remedies.  (Iji
   Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan)  V.1-    1964-
   Volume(issue)/page/year: 11,2533,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1540 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 19,615,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   SHNSAS Shinryo to Shinyaku.  Medical Consultation and New Remedies.  (Iji
   Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan)  V.1-    1964-
   Volume(issue)/page/year: 11,2533,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   SHNSAS Shinryo to Shinyaku.  Medical Consultation and New Remedies.  (Iji
   Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan)  V.1-    1964-
   Volume(issue)/page/year: 11,2533,1974
 
                            *** END OF RECORD ***