*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ZG1005000
CHEMICAL NAME           : 20-alpha-Yohimban-16-beta-carboxylic acid,
                          17-alpha-hydroxy-, methyl ester
CAS REGISTRY NUMBER     : 131-03-3
LAST UPDATED            : 198708
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H26-N2-O3
MOLECULAR WEIGHT        : 354.49
WISWESSER LINE NOTATION : T F6 D5 C666 EM ON&&TTTJ TQ UVO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Corynanthidine
   * 17-alpha-Hydroxy-20-alpha-yohimban-16-beta-carboxylic acid methyl ester
   * Isoyohimbine
   * alpha-Isoyohimbine
   * Mesoyohimbine
   * Rauwolscine
   * Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester,  
   (16-beta,17-alpha,20-alpha)-
   * alpha-Yohimbine
   * meso-Yohimbine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 134,447,1961
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
   Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
    Volume(issue)/page/year: -,317,1948
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 134,447,1961
 
                            *** END OF RECORD ***