*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : ZG0700000
CHEMICAL NAME : 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid,
18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl ester,
3,4,5-trimethoxycinnamate (ester)
CAS REGISTRY NUMBER : 24815-24-5
BEILSTEIN REFERENCE NO. : 0075328
REFERENCE : 4-25-00-01323 (Beilstein Handbook Reference)
LAST UPDATED : 199803
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C35-H42-N2-O9
MOLECULAR WEIGHT : 634.79
WISWESSER LINE NOTATION : T F6 D5 C666 EM ON&&TTTJ HO1 SOV1U1R CO1 DO1 EO1& TO1
UVO1
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Anaprel
* Apoterin
* Cartric
* Cinamine
* Cinnaloid
* Methyl reserpate 3,4,5-trimethoxycinnamic acid ester
* Methyl 18-O-(3,4,5-trimethoxycinnamoyl)reserpate
* Moderil
* Normorescina
* Raupyrol
* Raurescine
* Recinnamine
* Recitensina
* Rescaloid
* Rescamin
* Rescidan
* Rescinnamine
* Rescinpal
* Rescisan
* Resepinine (C35 alkaloid)
* Reserpinine
* Resipal
* Reskinnamin
* Scinnamina
* Tenamine
* Trimethoxycinnamoyl methyl reserpate
* Trimethoxy cinnamoyl reserpate de methyl
* 3,4,5-Trimethylcinnamic acid, ester with methyl reserpate
* 3,4,5-Trimethylcinnamoyl methyl reserpate
* Tuareg
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 4 ug/kg/D
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Behavioral - somnolence (general depressed activity)
Behavioral - antipsychotic
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
Academic Press, Inc., 1969 Volume(issue)/page/year: -,517,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,898,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,898,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,898,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,109,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark
Office, Foreign Patents, Washington, DC 20231) Discontinued.
Volume(issue)/page/year: #5226M
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 263 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark
Office, Foreign Patents, Washington, DC 20231) Discontinued.
Volume(issue)/page/year: #5226M
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#00965
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 23,600,1973
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE : 32 ug/kg
SEX/DURATION : male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
80,239,1982
*** END OF RECORD ***