*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ZG0600000
CHEMICAL NAME           : 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid,
                          18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl ester,
                          3,4,5-trimethoxybenzoate (ester), phosphate
CAS REGISTRY NUMBER     : 1263-94-1
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C33-H40-N2-O9.xH3-O4-P
MOLECULAR WEIGHT        : 1294.75
WISWESSER LINE NOTATION : T F6 D5 C666 EM ON&&TTTJ CVO1 HO1 SOVR CO1 DO1 EO1&
                          TO1 &..H2.P-O4
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Reserpine phosphate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 138,78,1962
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 ug/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - postpartum
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   JNEUAY Journal of Neuropsychiatry.  (Chicago, IL)  V.1-5, 1959-64.  For
   publisher information, see BENPBG.  Volume(issue)/page/year: 4,87,1962
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 ug/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   JNEUAY Journal of Neuropsychiatry.  (Chicago, IL)  V.1-5, 1959-64.  For
   publisher information, see BENPBG.  Volume(issue)/page/year: 4,87,1962
 
                            *** END OF RECORD ***