*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ZG0560000
CHEMICAL NAME           : 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid,
                          18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl ester,
                          3,4,5-trimethoxybenzoate (ester), mixt. with
                          1-hydrazinophthalazine
LAST UPDATED            : 199206
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C33-H40-N2-O9.C8-H8-N4
MOLECULAR WEIGHT        : 768.95
WISWESSER LINE NOTATION : T F6 D5 C666 EM ON&&TTTJ HO1 SOVR CO1 DO1 EO1& TO1
                          UVO1 &T66 CNNJ BMZ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Apresoline-serpasil
   * Reserpine-hydralazine
   * Serpasil-apresoline
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3320 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - nausea or vomiting
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 4,2789,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1770 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 4,2789,1976
 
                            *** END OF RECORD ***