*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ZF0350000
CHEMICAL NAME           : 2,5-Xylidine, hydrochloride
CAS REGISTRY NUMBER     : 51786-53-9
LAST UPDATED            : 199012
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C8-H11-N.Cl-H
MOLECULAR WEIGHT        : 157.66
WISWESSER LINE NOTATION : ZR B1 E1 &GH
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * 1-Amino-2,5-dimethylbenzene hydrochloride
   * 3-Amino-1,4-dimethylbenzene hydrochloride
   * 5-Amino-1,4-dimethylbenzene hydrochloride
   * 2-Amino-4-methyltoluene hydrochloride
   * 2-Amino-1,4-xylene hydrochloride
   * 2,5-Dimethyl aniline hydrochloride
   * 2,5-Dimethylaniline hydrochloride
   * 2,5-Dimethylbenzenamine hydrochloride
   * 5-Methyl-o-toluidine hydrochloride
   * 6-Methyl-m-toluidine hydrochloride
   * para-Xylidine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 770 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the
   National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial
   Ave., Cambridge, MA 02141)  Volume(issue)/page/year: NCI-E-68-1311,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the
   National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial
   Ave., Cambridge, MA 02141)  Volume(issue)/page/year: NCI-E-68-1311,1973
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 124 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(2),325,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 390 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Liver - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(2),325,1978
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 248 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(2),325,1978
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 780 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(2),325,1978
 
                            *** END OF RECORD ***