*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ZE4655000
CHEMICAL NAME           : p-Xylene,
                          alpha,alpha,alpha,alpha',alpha',alpha'-hexachloro-
CAS REGISTRY NUMBER     : 68-36-0
BEILSTEIN REFERENCE NO. : 2051282
REFERENCE               : 4-05-00-00968 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C8-H4-Cl6
MOLECULAR WEIGHT        : 312.82
WISWESSER LINE NOTATION : GXGGR DXGGG
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Benzene, 1,4-bis(trichloromethyl)-
   * Bitriben
   * 1,4-Bis-trichloromethyl benzene
   * Chloksil
   * Chloxil
   * Chloxyl
   * Cloxil
   * alpha,alpha'-Hexachloroxylene
   * alpha,alpha,alpha,alpha',alpha',alpha'-Hexachloro-p-xylene
   * p-Xylene, alpha,alpha,alpha,alpha',alpha',alpha'-hexachloro-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GNAMAP Gigiena Naselennykh Mest.  Hygiene in Populated Places. (Izdatel'stvo
   Zdorov'ya, Kiev, USSR) V.7-    1967- Volume(issue)/page/year: 21,34,1982
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 mg/kg/10D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
   etc.)
REFERENCE :
   ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete.  (VEB
   Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
   Rep.)  V.1-    1955-  Volume(issue)/page/year: 32,107,1986
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2330 mg/kg
SEX/DURATION            : male 26 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   GNAMAP Gigiena Naselennykh Mest.  Hygiene in Populated Places. (Izdatel'stvo
   Zdorov'ya, Kiev, USSR) V.7-    1967- Volume(issue)/page/year: 21,34,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2330 mg/kg
SEX/DURATION            : female 26 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   GNAMAP Gigiena Naselennykh Mest.  Hygiene in Populated Places. (Izdatel'stvo
   Zdorov'ya, Kiev, USSR) V.7-    1967- Volume(issue)/page/year: 21,34,1982

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-RUSSIA:STEL 10 mg/m3;Skin JAN 1993

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***