*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YY8158000
CHEMICAL NAME           : Vincaleukoblastine, O(sup
                          4)-deacetyl-3-de(methoxycarbonyl)-3-(((2-ethoxy-1-(1H
                          -indol-3- ylmethyl)-2-oxoethyl)amino)carbonyl)-,
                          (23(S))-
CAS REGISTRY NUMBER     : 81600-06-8
LAST UPDATED            : 199403
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C56-H68-N6-O9
MOLECULAR WEIGHT        : 969.30
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Vintriptol
   * V-L-Trp-OEt
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 94 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 28,1079,1985
 
                            *** END OF RECORD ***