*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YY8154000
CHEMICAL NAME           : Vincaleukoblastine, O(sup
                          4)-deacetyl-3-de(methoxycarbonyl)-3-(((1-(diethoxypho
                          sphinyl)-2- methylpropyl)amino)carbonyl)-, (3(S))-,
                          sulfate (salt)
CAS REGISTRY NUMBER     : 123286-01-1
LAST UPDATED            : 199406
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C51-H72-N5-O10-P.xH2-O4-S
MOLECULAR WEIGHT        : 1632.81
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * S 12363
   * Servier-12363
   * Vinfosiline sulfate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 110 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   16,822,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 620 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   16,822,1991
 
                            *** END OF RECORD ***